Self-limiting hypersalivation due to grooming was observed on the day of treatment in both treatment groups (6/8 cats in the 1× group and 7/8 cats in the 3× group). The safety of BRAVECTO has not been established in breeding, pregnant and lactating cats. Fluralaner, one of the ingredients in Bravecto Plus, is a member of the isoxazoline class. These adverse events occurred within 48 hours of administration. Bravecto Plus for Cats is a safe and effective topical flea and tick treatment that treats fleas, ticks, gastrointestinal nematodes and prevents heartworm in cats. If contact with eyes occurs, then flush eyes slowly and gently with water. Out of scope - Out of scope for RxNorm and will not receive RxNorm normal forms. Compared to other products which must be given every month. Two untreated cats were found dead prior to dosing. Doses of BRAVECTO® for dogs and BRAVECTO® for cats are counted separately and cannot be added together when determining rebate amounts. View Labeling Archives, Inactive ingredients: dimethylacetamide, glycofurol, diethyltoluamide, acetone, butylhydroxytoluene. Each tube is formulated to provide a minimum dose of 18.2 mg/lb (40 mg/kg) fluralaner and 0.9 mg/lb (2 mg/kg) moxidectin. In addition, three treated cats (2/8 cats in the 1× group and 1/8 cats in the 3× group) developed adverse neurologic signs during the study and were euthanized due to quality-of-life concerns. Each tube is packaged individually in a pouch. These adverse events occurred within 48 hours of administration. A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Bravecto Plus topically to cats prior to first use. Bravecto for Cats requires a prescription from your veterinarian. It is exclusively indicated when use against ticks or fleas and one or more of the other target parasites is indicated at the same time. Do not eat, drink or smoke while handling the product. If a dose is missed and a 2-month interval between doses is exceeded, administer Bravecto Plus immediately and resume the dosing every 2 months. Bravecto Plus has not been shown to be effective in kittens less than 6 months of age. In well-controlled laboratory studies, Bravecto Plus demonstrated ≥ 98.1% effectiveness against Ixodes scapularis 48 hours after treatment or infestation for 2 months. Clinical signs in one cat in the 1× group included vomiting, depression, vocalization, and ataxia 38 days after dosing. Peak fluralaner concentrations are achieved between 3 and 21 days following topical administration and the elimination half-life ranges between 11 and 18 days. When fleas and ticks bite, they ingest the solution and die within 8 hours. In a European field study for fluralaner topical solution for cats, there were three reports of facial dermatitis in humans after close contact with the application site which occurred within 4 days of application. (fluralaner and moxidectin topical solution) for Cats. Bravecto Plus is available in three tube sizes to treat cats ranging in weight from 2.6 lb - 27.5 lb (1.2 kg to 12.5 kg). Reg. If a second spot is needed to avoid run off, then apply the second spot slightly behind the first spot. 0061-5998-02, The cap is designed to stay on the tube for dosing and should not be removed. No clinical signs associated with liver disease were noted in these cats. Each milliliter contains 280 mg of fluralaner and 14 mg of moxidectin. For cats suffering from, or at risk of, mixed ecto- and endoparasitic infestations. should be administered the appropriate combination of tubes. Bravecto Plus should be administered topically as a single dose every 2 months according to the Dosage Schedule below to provide a minimum dose of 18.2 mg/lb (40 mg/kg) fluralaner and 0.9 mg/lb (2 mg/kg) moxidectin. Not for human use. Percentage of Cats with Adverse Reactions (AR) in the Field Study, Safety in cats infected with adult heartworm (Dirofilaria immitis), All Drug Cosmetic changes at the application site included matting/clumping/spiking of hair, wetness, or a greasy appearance. These cats also had mild elevations of aspartate aminotransferase (AST) (less than twice the upper reference range of 100 IU/L). BRAVECTO® PLUS . Bravecto Plus is available in three tube sizes to treat cats ranging in weight from 2.6 lb – 27.5 lb (1.2 kg to 12.5 kg). The safety of Bravecto Plus has not been established in breeding, pregnant, and lactating cats. After applying Bravecto for Cats, the medication quickly reaches tissue fluids under your cat's skin. If a dose is missed and a 2-month interval between doses is exceeded, administer Bravecto Plus immediately and resume the dosing every 2 months. Store in the original package in order to protect from moisture. Citations, PRINCIPAL DISPLAY PANEL - 112.5 mg/5.6 mg Tube Pouch Carton, PRINCIPAL DISPLAY PANEL - 250 mg/12.5 mg Tube Pouch Carton, PRINCIPAL DISPLAY PANEL - 500 mg/25 mg Tube Pouch Carton, (What Bravecto Plus was not effective when administered more than 2 months prior to infection. Avoid contact with skin and eyes. Safety in cats infected with adult heartworm (Dirofilaria immitis): Bravecto Plus was administered topically to cats infected with adult heartworm at 1X or 3X the maximum labeled dose of 93.0 mg fluralaner/kg and 4.7 mg moxidectin/kg (8 cats per group). View NDC Code(s)NEW! Do not contact or allow children to contact the application site until 2 hours post application. The chemical name of moxidectin is (2aE,4E,5’R,6R,6’S,8E,11R,13S,15S,17aR, 20R,20aR,20bS)-6’-[(E)-1,3-Dimethyl-1-butenyl]-5’,6,6’,7,10,11, 14,15,17a,20,20a,20b - dodecahydro - 20,20b - dihydroxy - 5’,6,8,19 - tetramethylspiro[11,15 - methano - 2H,13H,17H - furo[4,3,2 - pq][2,6] benzodioxacyclooctadecin-13,2’-[2H]pyran]-4’,17(3’H)-dione 4’-(E)-(O-methyloxime). Avoid oral ingestion (see Animal Safety). * 3 Cats over 27.5 lb. For prevention of heartworm disease, Bravecto Plus should be administered at 2-month intervals. For Medium Cats . DailyMed will deliver this notification to your desktop, Web browser, or e-mail depending on the RSS Reader you select to use. Wash hands and contacted skin thoroughly with soap and water immediately after use of the product. To report suspected adverse events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Merck Animal Health at 1-800-224-5318. In two well-controlled laboratory studies, Bravecto Plus was 100% effective against induced heartworm infections when administered 2 months prior to infection. Bravecto Plus may be administered year-round without interruption or at a minimum should be administered at 2-month intervals beginning at the cat's first seasonal exposure to mosquitoes and continuing until the cat's last seasonal exposure to mosquitoes. To report suspected adverse events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Merck Animal Health at 1-800-224-5318. Keep away from heat, sparks, open flame or other sources of ignition. If you are a consumer or patient please visit The cap should be rotated clockwise or counter clockwise one full turn. One cat within 4 hours of use developed ataxia involving loss of use of back legs, head tremor and has had to go into the Vet for overnight observation in case she developed fits. 3 doses of BRAVECTO® per pet, get a rebate of $20; 4 doses of BRAVECTO® per pet, get a rebate of $30. There were no clinically-relevant, treatment-related effects on body weights, clinical pathology (hematology, clinical chemistry, and coagulation profile), gross pathology or histopathology. Copy the URL below and paste it into your RSS Reader application. PubMed, Keep this and all drugs out of the reach of children. Avoid oral ingestion. Self-limiting hypersalivation due to grooming was observed on the day of treatment in both treatment groups (6/8 cats in the 1X group and 7/8 cats in the 3X group). Bravecto Plus spot-on for cats works fast and continues to protect against fleas for 3 months, paralysis ticks for 10 weeks and heartworm for 2 months, plus treats roundworm, hookworm and ear mites. Part the hair and apply to the skin on the back of the head, as per the diagram. published 4 months ago. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. The cap should be rotated clockwise or counter clockwise one full turn. Avoid contact with skin and eyes. For prevention of heartworm disease, Bravecto Plus should be administered at 2-month intervals. Keep away from heat, sparks, open flame or other sources of ignition. SAVE MORE WITH BRAVECTO ®. Show. Fleas are killed in up to 12 hours after treatment or after reinfestation during the 3 month treatment period. One treated kitten experienced vomiting 2 hours after administration and another 8 hours after treatment. In a well-controlled laboratory study, Bravecto Plus killed 100% of fleas within 12 hours after treatment and reduced the numbers of live fleas on cats by >99% within 12 hours after treatment or infestation for 2 months. In well-controlled laboratory studies, Bravecto Plus was effective against naturally and experimentally induced adult and experimentally induced 4th stage larval and immature adult Toxocara cati and Ancylostoma tubaeforme infections in cats. The seal was broken on the first pack of Bravecto Plus for cats I purchased. Step 2: The cat should be standing or lying with its back horizontal during application. One stop treatment shop for dogs and cats to prevent nasty parasites from damaging their health. Once administered, the formula spreads throughout the body and results starts to show only within 48 hours. Put on gloves. Avoid oral ingestion (see Animal Safety). Wash hands and contacted skin thoroughly with soap and water immediately after use of the product. Kills fleas, ticks, roundworms, hookworms and prevents heartworm disease for 2 months. 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